Endocrine Abstracts

Purpose: To establish the safety and efficacy of multikinase inhibitors (MKIs) treatment in real life.Methods: This retrospective observational descriptive study included patients with advanced differentiated thyroid cancer in treatment with MKIs as first and second line treatment. From November 2011 to May 2022. Clinical variables, efficacy and adverse events (AE) were collected. Variables are expressed as median and interquartile range.<p class="ab...

Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in several tumour types, leading to oncogenic splicing events associated with tumour progression and aggressiveness. However, whether this molecular phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, our main aim was to explore the potential dysregulation of the expression of relevant spliceosome components and splicing factors in clinic...

Introduction: The incidence of thyroid cancer (TC) is low, but rising over time. Some studies point to a possible increase in mortality rate (MR) from this cancer in certain areas of Spain and Andalusia. Our purpose was to analyse the TC mortality in Andalusia and study how it has changed in the last years. We also analysed differences by age, sex, and geographic area.Methods: All deaths from TC were collected between January 1, 1975 and December 1, 2011...